This special issue of The Global South asks how the rise and persistent relevance of radio has shaped and been shaped by the cultures of the Global South over the past century and more. What art forms, social practices, political movements, and linguistic effects emerged through the radio speakers of the Global South? How have creators and consumers harnessed this medium and its expressive possibilities? What roles has radio played in the broader cultural histories of the Global South? Here, the “Global South” is used as a flexible descriptor that names not only nations and lands of the southern hemisphere, but other regions radically affected by the pressures of imperialism, globalization, and unequal development.