Call for book review- Osteoimmunopathology: Evidence-Based Perspectives from Molecular Biology to Systems Biology

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By Francesco Chiappelli

2011 | Springer
Copy Available: Yes

Language: English
ISBN: 978-1-4419-9494-3

Osteoimmunopathology pertains to the study of the relationship between the bones,particularly the bone marrow, and the immune system. Th is monograph pursues thebest available evidence, by means of research synthesis, for the characterization of thephysiological relevance and pathological implications of the inter-connectedness betweenthe skeletal and the immune system. Research will be discussed that highlights the associatedrole of the circulatory, nervous and endocrine systems, as well as proteomic andgenomic pathways and signatures. Emphasis is given to the oral cavity, its diseases, andtheir systemic sequelae. Th is monograph arises from observations that have suggestedthat the skeletal system and the immune system are intimately intertwined. Chronicinfl ammatory reactions subsequent to an excessive immune reaction can damage thebones, as in rheumatoid arthritis (RA), osteoporosis, patients seropositive for thehuman immunodefi ciency virus and with signs and symptoms of the acquiredimmune defi ciency syndrome (AIDS), and bone cancer. Bones – in particular the bonemarrow – are one of the primary locations in which cells of the immune system mature.In brief, this monograph begins to answer a range of questions, such as:
• What is Osteoimmunopathology all about?
• Does the immune system and its components aff ect bone development?
• How do stress hormones impact upon the pathophysiology of bone-immuneinteractions?
• Can the scientifi c process of research synthesis obtain the best available evidencefor treatment of diseases involving the bone-immune entity?