This panel seeks papers that explore the early modern relationship between loss and melancholy for the Sixteenth Century Society Conference to be held in Chicago, 29-31 October 2026. In his Anatomy of Melancholy (1621), Robert Burton writes, “Now go and brag of thy present happiness… thou seest in what a brittle state thou art, how soon thou mayst be dejected… by bad diet, bad air, a small loss, a little sorrow or discontent.” Bereavement permeates the early modern landscape, appearing in paintings, prints, poems, plays, ego documents, and legal testimony, among many other sources. It may involve the loss of love, friends, honor, possessions, homeland, freedom, political stability, or even religious conviction.